The use of first order derivative spectrophotometry allows simultaneous determination of Pantoprazole and Domperidone in fixed dose combination products. The wavelengths 287 nm and 289.99 nm of first derivative spectrum were selected for the estimation of pantoprazole and domperidone, respectively without mutual interference. The method was linear in the concentration range 8-40 μg/ml and 2-10 μg/ml for pantoprazole and domperidone, respectively. The method was validated in terms of accuracy and precision. The result of the formulation analysis shows that the proposed method can be successfully used for the simultaneous estimation of both the drugs in their combined dosage form.
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